Z16

ICD-10Non-billable category

Resistance to antimicrobial drugs

Official ICD-10-CM descriptor (FY2026)

Resistance to antimicrobial drugs

Z16 is a category heading, not a billable code. CMS does not accept it on a claim; report one of the more specific codes beneath it.

Excludes1

Not coded here. An Excludes1 code should never be reported at the same time as the code above it.

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first

Sequence the underlying condition before this code.

the infection

Notes

The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

More specific codes under Z16

Where this code sits

Chapter: 21. Factors influencing health status and contact with health services (Z00-Z99)
Block: Resistance to antimicrobial drugs (Z16)

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Source

ICD-10-CM FY2026. Centers for Medicare & Medicaid Services (CMS) / National Center for Health Statistics (NCHS), “2026 ICD-10-CM Code Descriptions in Tabular Order” (icd10cm_order_2026.txt). Download the original file from cms.gov. Public domain (US Government work). Descriptors, billable flags and instructional notes on this page are reproduced from that file without modification. Krasyn adds no clinical guidance.