C49
ICD-10Non-billable categoryMalignant neoplasm of other connective and soft tissue
Official ICD-10-CM descriptor (FY2026)
Malignant neoplasm of other connective and soft tissue
C49 is a category heading, not a billable code. CMS does not accept it on a claim; report one of the more specific codes beneath it.
Includes
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
Excludes1
Not coded here. An Excludes1 code should never be reported at the same time as the code above it.
- malignant neoplasm of cartilage (of):
- articular (C40-C41)
- larynx (C32.3)
- nose (C30.0)
- malignant neoplasm of connective tissue of breast (C50.-)
Excludes2
Not included here. The condition is not part of this code, but a patient may have both, and both codes may be reported together.
- Kaposi's sarcoma of soft tissue (C46.1)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- malignant neoplasm of peritoneum (C48.2)
- malignant neoplasm of retroperitoneum (C48.0)
- malignant neoplasm of uterine ligament (C57.3)
- mesothelioma (C45.-)
More specific codes under C49
- C49.0Malig neoplm of conn and soft tissue of head, face and neck
- C49.1Malig neoplm of conn and soft tiss of upper limb, inc shldrcategory
- C49.2Malig neoplm of conn and soft tissue of lower limb, inc hipcategory
- C49.3Malignant neoplasm of connective and soft tissue of thorax
- C49.4Malignant neoplasm of connective and soft tissue of abdomen
- C49.5Malignant neoplasm of connective and soft tissue of pelvis
- C49.6Malignant neoplasm of conn and soft tissue of trunk, unsp
- C49.8Malignant neoplasm of ovrlp sites of conn and soft tissue
- C49.9Malignant neoplasm of connective and soft tissue, unsp
- C49.AGastrointestinal stromal tumorcategory
Where this code sits
- Chapter
- 2. Neoplasms (C00-D49)
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ICD-10-CM FY2026. Centers for Medicare & Medicaid Services (CMS) / National Center for Health Statistics (NCHS), “2026 ICD-10-CM Code Descriptions in Tabular Order” (icd10cm_order_2026.txt). Download the original file from cms.gov. Public domain (US Government work). Descriptors, billable flags and instructional notes on this page are reproduced from that file without modification. Krasyn adds no clinical guidance.