C00-D49
ICD-10-CM Chapter 2: Neoplasms
Chapter 2 of the ICD-10-CM tabular list covers C00-D49. It contains 23 blocks of related categories, listed below with the categories published in each.
Notes
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
C00-C96 — Malignant neoplasms
C00-C75 — Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue
C00-C14 — Malignant neoplasms of lip, oral cavity and pharynx
- C00Malignant neoplasm of lipcategory
- C01Malignant neoplasm of base of tongue
- C02Malignant neoplasm of other and unspecified parts of tonguecategory
- C03Malignant neoplasm of gumcategory
- C04Malignant neoplasm of floor of mouthcategory
- C05Malignant neoplasm of palatecategory
- C06Malignant neoplasm of other and unspecified parts of mouthcategory
- C07Malignant neoplasm of parotid gland
- C08Malignant neoplasm of other and unsp major salivary glandscategory
- C09Malignant neoplasm of tonsilcategory
- C10Malignant neoplasm of oropharynxcategory
- C11Malignant neoplasm of nasopharynxcategory
- C12Malignant neoplasm of pyriform sinus
- C13Malignant neoplasm of hypopharynxcategory
- C14Malig neoplasm of sites in the lip, oral cavity and pharynxcategory
C15-C26 — Malignant neoplasms of digestive organs
- C15Malignant neoplasm of esophaguscategory
- C16Malignant neoplasm of stomachcategory
- C17Malignant neoplasm of small intestinecategory
- C18Malignant neoplasm of coloncategory
- C19Malignant neoplasm of rectosigmoid junction
- C20Malignant neoplasm of rectum
- C21Malignant neoplasm of anus and anal canalcategory
- C22Malignant neoplasm of liver and intrahepatic bile ductscategory
- C23Malignant neoplasm of gallbladder
- C24Malignant neoplasm of other and unsp parts of biliary tractcategory
- C25Malignant neoplasm of pancreascategory
- C26Malignant neoplasm of other and ill-defined digestive organscategory
C30-C39 — Malignant neoplasms of respiratory and intrathoracic organs
- C30Malignant neoplasm of nasal cavity and middle earcategory
- C31Malignant neoplasm of accessory sinusescategory
- C32Malignant neoplasm of larynxcategory
- C33Malignant neoplasm of trachea
- C34Malignant neoplasm of bronchus and lungcategory
- C37Malignant neoplasm of thymus
- C38Malignant neoplasm of heart, mediastinum and pleuracategory
- C39Malig neoplm of sites in the resp sys and intrathorac organscategory
C40-C41 — Malignant neoplasms of bone and articular cartilage
C43-C44 — Melanoma and other malignant neoplasms of skin
C45-C49 — Malignant neoplasms of mesothelial and soft tissue
C50 — Malignant neoplasms of breast
C51-C58 — Malignant neoplasms of female genital organs
- C51Malignant neoplasm of vulvacategory
- C52Malignant neoplasm of vagina
- C53Malignant neoplasm of cervix utericategory
- C54Malignant neoplasm of corpus utericategory
- C55Malignant neoplasm of uterus, part unspecified
- C56Malignant neoplasm of ovarycategory
- C57Malignant neoplasm of other and unsp female genital organscategory
- C58Malignant neoplasm of placenta
C60-C63 — Malignant neoplasms of male genital organs
C64-C68 — Malignant neoplasms of urinary tract
C69-C72 — Malignant neoplasms of eye, brain and other parts of central nervous system
C73-C75 — Malignant neoplasms of thyroid and other endocrine glands
C7A — Malignant neuroendocrine tumors
C7B — Secondary neuroendocrine tumors
C76-C80 — Malignant neoplasms of ill-defined, other secondary and unspecified sites
- C76Malignant neoplasm of other and ill-defined sitescategory
- C77Secondary and unspecified malignant neoplasm of lymph nodescategory
- C78Secondary malignant neoplasm of resp and digestive organscategory
- C79Secondary malignant neoplasm of other and unspecified sitescategory
- C80Malignant neoplasm without specification of sitecategory
C81-C96 — Malignant neoplasms of lymphoid, hematopoietic and related tissue
- C81Hodgkin lymphomacategory
- C82Follicular lymphomacategory
- C83Non-follicular lymphomacategory
- C84Mature T/NK-cell lymphomascategory
- C85Oth and unspecified types of non-Hodgkin lymphomacategory
- C86Other specified types of T/NK-cell lymphomacategory
- C88Malig immunoproliferative dis and certain oth B-cell lymphcategory
- C90Multiple myeloma and malignant plasma cell neoplasmscategory
- C91Lymphoid leukemiacategory
- C92Myeloid leukemiacategory
- C93Monocytic leukemiacategory
- C94Other leukemias of specified cell typecategory
- C95Leukemia of unspecified cell typecategory
- C96Oth & unsp malig neoplm of lymphoid, hematpoetc and rel tisscategory
D00-D09 — In situ neoplasms
- D00Carcinoma in situ of oral cavity, esophagus and stomachcategory
- D01Carcinoma in situ of other and unspecified digestive organscategory
- D02Carcinoma in situ of middle ear and respiratory systemcategory
- D03Melanoma in situcategory
- D04Carcinoma in situ of skincategory
- D05Carcinoma in situ of breastcategory
- D06Carcinoma in situ of cervix utericategory
- D07Carcinoma in situ of other and unspecified genital organscategory
- D09Carcinoma in situ of other and unspecified sitescategory
D10-D36 — Benign neoplasms, except benign neuroendocrine tumors
- D10Benign neoplasm of mouth and pharynxcategory
- D11Benign neoplasm of major salivary glandscategory
- D12Benign neoplasm of colon, rectum, anus and anal canalcategory
- D13Benign neoplasm of and ill-defined parts of digestive systemcategory
- D14Benign neoplasm of middle ear and respiratory systemcategory
- D15Benign neoplasm of other and unsp intrathoracic organscategory
- D16Benign neoplasm of bone and articular cartilagecategory
- D17Benign lipomatous neoplasmcategory
- D18Hemangioma and lymphangioma, any sitecategory
- D19Benign neoplasm of mesothelial tissuecategory
- D20Benign neoplm of soft tissue of retroperiton and peritoneumcategory
- D21Other benign neoplasms of connective and other soft tissuecategory
- D22Melanocytic nevicategory
- D23Other benign neoplasms of skincategory
- D24Benign neoplasm of breastcategory
- D25Leiomyoma of uteruscategory
- D26Other benign neoplasms of uteruscategory
- D27Benign neoplasm of ovarycategory
- D28Benign neoplasm of other and unsp female genital organscategory
- D29Benign neoplasm of male genital organscategory
- D30Benign neoplasm of urinary organscategory
- D31Benign neoplasm of eye and adnexacategory
- D32Benign neoplasm of meningescategory
- D33Benign neoplasm of brain and oth prt central nervous systemcategory
- D34Benign neoplasm of thyroid gland
- D35Benign neoplasm of other and unspecified endocrine glandscategory
- D36Benign neoplasm of other and unspecified sitescategory
D3A — Benign neuroendocrine tumors
D37-D48 — Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
- D37Neoplasm of uncrt behavior of oral cavity and dgstv organscategory
- D38Neoplm of uncrt behav of mid ear & resp and intrathorac orgcategory
- D39Neoplasm of uncertain behavior of female genital organscategory
- D40Neoplasm of uncertain behavior of male genital organscategory
- D41Neoplasm of uncertain behavior of urinary organscategory
- D42Neoplasm of uncertain behavior of meningescategory
- D43Neoplasm of uncertain behavior of brain and cnslcategory
- D44Neoplasm of uncertain behavior of endocrine glandscategory
- D45Polycythemia vera
- D46Myelodysplastic syndromescategory
- D47Oth neoplm of uncrt behav of lymphoid, hematpoetc & rel tisscategory
- D48Neoplasm of uncertain behavior of other and unsp sitescategory
D49 — Neoplasms of unspecified behavior
Source
ICD-10-CM FY2026. Centers for Medicare & Medicaid Services (CMS) / National Center for Health Statistics (NCHS), “2026 ICD-10-CM Code Descriptions in Tabular Order” (icd10cm_order_2026.txt). Download the original file from cms.gov. Public domain (US Government work). Descriptors, billable flags and instructional notes on this page are reproduced from that file without modification. Krasyn adds no clinical guidance.