C00-D49

ICD-10-CM Chapter 2: Neoplasms

Chapter 2 of the ICD-10-CM tabular list covers C00-D49. It contains 23 blocks of related categories, listed below with the categories published in each.

Notes

  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

C00-C96: Malignant neoplasms

C00-C75: Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue

C00-C14: Malignant neoplasms of lip, oral cavity and pharynx

C15-C26: Malignant neoplasms of digestive organs

C30-C39: Malignant neoplasms of respiratory and intrathoracic organs

C40-C41: Malignant neoplasms of bone and articular cartilage

C43-C44: Melanoma and other malignant neoplasms of skin

C45-C49: Malignant neoplasms of mesothelial and soft tissue

C50: Malignant neoplasms of breast

C51-C58: Malignant neoplasms of female genital organs

C60-C63: Malignant neoplasms of male genital organs

C64-C68: Malignant neoplasms of urinary tract

C69-C72: Malignant neoplasms of eye, brain and other parts of central nervous system

C73-C75: Malignant neoplasms of thyroid and other endocrine glands

C7A: Malignant neuroendocrine tumors

C7B: Secondary neuroendocrine tumors

C76-C80: Malignant neoplasms of ill-defined, other secondary and unspecified sites

C81-C96: Malignant neoplasms of lymphoid, hematopoietic and related tissue

D00-D09: In situ neoplasms

D10-D36: Benign neoplasms, except benign neuroendocrine tumors

D3A: Benign neuroendocrine tumors

D37-D48: Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

D49: Neoplasms of unspecified behavior

Source

ICD-10-CM FY2026. Centers for Medicare & Medicaid Services (CMS) / National Center for Health Statistics (NCHS), “2026 ICD-10-CM Code Descriptions in Tabular Order” (icd10cm_order_2026.txt). Download the original file from cms.gov. Public domain (US Government work). Descriptors, billable flags and instructional notes on this page are reproduced from that file without modification. Krasyn adds no clinical guidance.

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