D81
ICD-10Non-billable categoryCombined immunodeficiencies
Official ICD-10-CM descriptor (FY2026)
Combined immunodeficiencies
D81 is a category heading, not a billable code. CMS does not accept it on a claim; report one of the more specific codes beneath it.
Excludes1
Not coded here. An Excludes1 code should never be reported at the same time as the code above it.
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
More specific codes under D81
- D81.0Severe combined immunodeficiency with reticular dysgenesis
- D81.1Severe combined immunodeficiency w low T- and B-cell numbers
- D81.2Severe combined immunodef w low or normal B-cell numbers
- D81.3Adenosine deaminase [ADA] deficiencycategory
- D81.4Nezelof's syndrome
- D81.5Purine nucleoside phosphorylase [PNP] deficiency
- D81.6Major histocompatibility complex class I deficiency
- D81.7Major histocompatibility complex class II deficiency
- D81.8Other combined immunodeficienciescategory
- D81.9Combined immunodeficiency, unspecified
Where this code sits
Krasyn AI Coder
Get code suggestions automatically as you type notes. Free for 50 analyses.
Install for Chrome — freeSource
ICD-10-CM FY2026. Centers for Medicare & Medicaid Services (CMS) / National Center for Health Statistics (NCHS), “2026 ICD-10-CM Code Descriptions in Tabular Order” (icd10cm_order_2026.txt). Download the original file from cms.gov. Public domain (US Government work). Descriptors, billable flags and instructional notes on this page are reproduced from that file without modification. Krasyn adds no clinical guidance.